Research Archive · Curated Literature
Scientific Literature
Curated reference literature on bremelanotide mechanism, clinical pharmacology, and neurobiology. All references drawn from peer-reviewed journals.
PT-141: A melanocortin agonist for the treatment of sexual dysfunction.
Molinoff PB, et al. · Ann N Y Acad Sci 2003 · 994:96–102
Seminal mechanism paper. Establishes MC4R agonism as pathway for CNS-mediated sexual response.
Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder.
Kingsberg SA, et al. · Obstet Gynecol 2019 · 134(5):899–908
Phase III RECONNECT trial. Statistically significant improvement in desire and distress vs. placebo.
Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization.
Hadley ME, Dorr RT. · Peptides 2006 · 27(4):921–930
Comprehensive review of melanocortin system history and receptor pharmacology.
Pathways of sexual desire.
Pfaus JG. · J Sex Med 2009 · 6(6):1506–1533
Neural circuitry of desire including dopaminergic, oxytocinergic, and melanocortinergic pathways.
Melanocortin receptors: perspectives for novel drugs.
Wikberg JE. · Eur J Pharmacol 2000 · 405(1–3):249–260
GPCR pharmacology of MC1R–MC5R subtypes with discussion of CNS expression patterns.
An effect on the subjective sexual response in premenopausal women with sexual arousal disorder.
Diamond LE, et al. · J Sex Med 2004 · 1(1):83–93
Early Phase II data demonstrating CNS-mediated response in women with arousal disorder.
Melanocortin receptor agonist in men with psychogenic erectile dysfunction.
Rosen RC, et al. · Int J Impot Res 2004 · 16(3):241–248
PT-141 phase II data in male population with psychogenic ED; central mechanism pathway confirmed.
Melanocortins and reproduction.
Schiöth HB, Watanobe H. · Brain Res Brain Res Rev 2014 · 73(1):12–24
Hypothalamic melanocortin receptor role in reproductive neuroendocrinology.
Archive is curated for mechanistic and clinical relevance. Search PubMed (PMID) or DOI for full-text access.